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انتشارات جدیدانتشارات 2014و 2015

  Cholestasis progression effects on long-term memory in bile duct ligation rats.

 Adv Biomed Res. 2014 Oct 20; 

Hosseini N 1 , Alaei H 2 , Zarrindast MR 3 , Nasehi M 4 , Radahmadi M 2 .

 Abstract

  BACKGROUND:

  There is evidence that cognitive functions are affected by some liver diseases such as cholestasis. Bile duct ligation induces cholestasis as a result of impaired liver function and cognition. This research investigates the effect of cholestasis progression on memory function in bile duct ligation rats.

  MATERIALS AND METHODS:

  MALE WISTAR RATS WERE RANDOMLY DIVIDED INTO FIVE GROUPS, WHICH INCLUDE: control group for BDL-7, control group for BDL-21, sham group (underwent laparotomy without bile duct ligation), BDL-7 group (7 days after bile duct ligation), and BDL-21 group (21 days after bile duct ligation). Step-through passive avoidance test was employed to examine memory function. In all groups, short-term (7 days after foot shock) and long-term memories (21 days after foot shock) were assessed.

  RESULTS:

  Our results showed that liver function significantly decreased with cholestasis progression (P < 0.01). Also our findings indicated BDL-21 significantly impaired acquisition time (P < 0.05). Memory retrieval impaired 7 (P < 0.05) and 21 days (P < 0.001) after foot shock in BDL-7 and BDL-21 groups, respectively.

  CONCLUSION:

  Based on these findings, liver function altered in cholestasis and memory (short-term and long-term memory) impaired with cholestasis progression in bile duct ligation rats. Further studies are needed to better insight the nature of progression of brain damage in cholestatic disease.

  KEYWORDS:

  Cholestasis; learning; memory; rat

 

  Link: http://www.ncbi.nlm.nih.gov/pubmed/25371872

 


 

Latent class analysis of DSM-5 criteria for opioid use disorders: results from the Iranian National Survey on Mental Health.

 Tarrahi MJ1, Rahimi-Movaghar A, Zeraati H, Motevalian SA, Amin-Esmaeili M, Hajebi A, Sharifi V, Radgoodarzi R, Hefazi M, Fotouhi A.

Eur Addict Res. 2015;21(3):144-52. doi: 10.1159/000369338. Epub 2015 Feb 11.Abstract

BACKGROUND:

 Assessments of DSM-IV and DSM-5 criteria with sample populations of opioid users are limited. This study aimed to determine the number of latent classes in opioid users and assessment of the proposed revisions to the DSM-5 opioid use disorder (OUD) criteria.

METHODS:

 Data came from the 2011 Iranian National Mental Health Survey (IranMHS) on 7,886 participants aged 15-64 years living in Iran. We used the Composite International Diagnostic Interview (CIDI) version 2.1 in all respondents who indicated using opioids at least 5 times in the previous 12 months (n = 236).

RESULTS:

 A three-class model provided the best fit of all the models tested. Classes showed a spectrum of severity that was compatible with the DSM-5 classification. 'Legal problems' and 'desire to cut down' showed poor discrimination between classes. The weighted prevalence of OUD using DSM-5 was 20.7% higher than with DSM-IV.

CONCLUSIONS:

 RESULTS support the grouping based on severity of symptoms, combining abuse and dependence into a single diagnosis, omitting legal problems, and addition of craving as a new criterion.

 

  http://www.ncbi.nlm.nih.gov/pubmed/25676055

 


 

  Modulation of the effects of the cannabinoid agonist, ACPA, on spatial and non-spatial novelty detection in mice by dopamine D1 receptor drugs infused into the basolateral amygdala

  By: Mohammadi, M (Mohammadi, Meisam)[ 1 ] ; Nasehi, M (Nasehi, Mohammad)[ 2 , 3 ] ; Zarrindast, MR (Zarrindast, Mohammad-Reza)[ 1 , 4 , 5 , 6 ]

  BEHAVIOURAL BRAIN RESEARCH

  Volume: 280

  Pages: 36-44

  DOI: 10.1016/j.bbr.2014.11.003

  Published: MAR 1 2015

  View Journal Information

  Abstract

  Aim: The amygdala is a major target of midbrain dopaminergic neurons and is implicated in learning and memory processes. This study investigates the effect of basolateral amygdale (BLA) dopamine receptors on spatial and non-spatial novelty detection deficit, induced by a selective CBI cannabinoid receptor agonist (Arachidonylcyclopropylamide; ACPA), during a non-associative task.

Methods: Male mice weighing 30-35 g were used. Open field procedure was employed to assess the spatial and non-spatial memory retention.

Results: Our data showed that post-training intraperitoneal injection of ACPA (0.02 mg/kg), intra-BLA microinjection of SKF38393 (D1 dopamine receptor agonist; at higher dose, 0.1 mu g/mouse) and SCH23390 (D1 dopamine receptor antagonist; at lowest dose, 0.005 mu g/mouse) impaired both spatial and non-spatial novelty detection. Moreover, intra-BLA microinjection of subthreshold dose of SKF38393 or SCH23390 restored and potentiated the spatial and non-spatial novelty detection impairment caused by ACPA, respectively.

Conclusion: Our results suggested that the ACPA induced impairment of memory retention, may occur through BLA D1 dopamine receptors. (C) 2014 Elsevier B.V. All rights reserved.

  http://apps.webofknowledge.com/InboundService.do?SID=V12d6CDP%40k5oGe7dii%40&product=WOS&UT=000348255400005&SrcApp=CR&DestFail=http%3A%2F%2Fwww.webofknowledge.com&Init=Yes&action=retrieve&Func=Frame&customersID=ResearchSoft&SrcAuth=ResearchSoft&IsProductCode=Yes&mode=FullRecord

 


 

Involvement of the serotonergic system of the ventral hippocampus (CA3) on amnesia induced by ACPA in mice.

 Nasehi M1, Kafi F2, Khakpai F3, Zarrindast MR4.

 Behav Brain Res. 2015 Jun

Abstract

 Interactions between the cannabinoid and serotonin systems have been reported in many studies. In the present study, we investigated the influence of the serotonergic receptor agents on amnesia induced by the cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA). Bilateral guide-cannulae were implanted to allow intra-CA3 microinjection of the drugs. The results showed that the intra-peritoneal (i.p.) injection of ACPA induce amnesia but did not alter head dip latency, head dip counts, and locomotion. Moreover, intra-CA3 injection of M-Chlorophenylbiguanide (M-CHL, a 5-HT3 serotonin receptor agonist), Y-25130 (a 5-HT3 serotonin receptor antagonist), RS67333 (a 5-HT4 serotonin receptor agonist), and RS23597-190 (a 5-HT4 serotonin receptor antagonist) impaired memory but have no effect on head dip latency and locomotor activity. In addition, intra-CA3 injection of Y-25130, RS67333, and RS23597-190 heighten the ACPA-induced amnesia and head dip counts while did not alter head dip latency and locomotor activity. On the other hand, intra-CA3 microinjection of M-CHL could not modify the ACPA-induced amnesia, head dip latency and locomotor activity whereas increased head dip counts. It can be concluded that the amnesia induced by i.p. administration of ACPA is at least partly mediated through the serotonergic receptor mechanism in the CA3 area.

  http://www.ncbi.nlm.nih.gov/pubmed/25771207

 


 

Influence of morphine on medial prefrontal cortex alpha2 adrenergic system in passive avoidance learning in rats.

 Torkaman-Boutorabi A1, Sheidadoust H2, Hashemi-Hezaveh SM2, Zarrindast MR3.

 Pharmacol Biochem Behav. 2015 Jun;133:92-8. doi: 10.1016/j.pbb.2015.03.018. Epub 2015 Apr 3.

Abstract

 The prelimbic region of the medial prefrontal cortex (mPFC) is a brain area crucial for memory, attention, and decision making. It has been shown that α2-adreneoceptors (α2-ARs) play a powerful role in regulating memory and attention functions in this region. Since many studies have demonstrated the impairment effect of morphine on memory through mPFC, we aimed to investigate the possible interaction between α2-ARs of the mPFC and morphine induced amnesia in passive avoidance learning in rats. Animals were bilaterally implanted with chronic cannulas in the mPFC, trained in the step-through type passive avoidance task, and tested 24h after training; step-through latencies were measured. Our data indicate that post-training i.p. administration of morphine (2.5, 5 and 7.5mg/kg) dose-dependently reduced the step-through latency, showing an amnesic effect. Post-training intra-mPFC administration of yohimbine (an α2-adrenergic antagonist, 0.125, 0.25 and 0.5μg/rat) and clonidine (an α2-adrenergic agonist, 0.001, 0.01 and 0.2μg/rat), dose dependently impaired memory retrieval. Furthermore, post-training intra-mPFC microinjection of ineffective doses of yohimbine or clonidine significantly reversed the inhibitory effect of morphine on memory retrieval. Furthermore, SKF96365 (a presynaptic calcium channel blocker) reduced yohimbine and showed slight inhibition of clonidine effect. These results suggest that α2-ARs of the mPFC may play an important role in morphine-induced amnesia.

  http://www.ncbi.nlm.nih.gov/pubmed/25847618

 

 


 

How does a group of Iranian youth conceptualize their risky sexual experiences?

 Noroozi M1, Merghati Khoei EA2, Taleghani F3, Tavakoli M4, Gholami A

 Iran Red Crescent Med J. 2015 Feb 21;17(2):e18301. doi: 10.5812/ircmj.18301. eCollection 2015.

Abstract

 BACKGROUND:

 There are restrictions as well as lawful and religious prohibition for sexual relationships in Iranian society.

OBJECTIVES:

 This study explores the varied experiential reality of Iranian youth and their risky sexual experiences.

PATIENTS AND METHODS:

 Data collection is based on semi-structured interviews with 30 single young men and women. Observation of interactions of youth in different settings has been another source of information. Interviews were microscopically content analyzed.

RESULTS:

 The accounts of risky sexual experiences included gendered behavioral, cultural, and cognitive factors. In the re-contextualizing process, these accounts were categorized by two main themes: "gendered sexual script" and "cultural scenarios of interpersonal interactions". The notion of "male power" was evident in the responses provided by the participants. Women seldom asked for condom use due to limited knowledge about STIs-HIV/AIDS and unpleasant experiences with condoms. Men had limited knowledge about various sexual modes of HIV and STIs transmission and did not use condoms consistently because they had not seen themselves at risk of STIs or HIV as well as their belief about the decrease of sexual pleasure.

CONCLUSIONS:

 Rising youth awareness, creating a positive attitude, and appropriate knowledge about safe sex practices are seminal. It is also vital to ensure access to gender specific sexual and reproductive health services for youths, empower women, and strengthen their sexual assertiveness as well as the elimination of all forms of gender-based inequalities

  http://www.ncbi.nlm.nih.gov/pubmed/25838931


Latent class analysis of DSM-5 criteria for opioid use disorders: results from the Iranian National Survey on Mental Health.

 Tarrahi MJ1, Rahimi-Movaghar A, Zeraati H, Motevalian SA, Amin-Esmaeili M, Hajebi A, Sharifi V, Radgoodarzi R, Hefazi M, Fotouhi A.

Eur Addict Res. 2015;21(3):144-52. doi: 10.1159/000369338. Epub 2015 Feb 11.

Abstract

 BACKGROUND:

 Assessments of DSM-IV and DSM-5 criteria with sample populations of opioid users are limited. This study aimed to determine the number of latent classes in opioid users and assessment of the proposed revisions to the DSM-5 opioid use disorder (OUD) criteria.

METHODS:

 Data came from the 2011 Iranian National Mental Health Survey (IranMHS) on 7,886 participants aged 15-64 years living in Iran. We used the Composite International Diagnostic Interview (CIDI) version 2.1 in all respondents who indicated using opioids at least 5 times in the previous 12 months (n = 236).

RESULTS:

 A three-class model provided the best fit of all the models tested. Classes showed a spectrum of severity that was compatible with the DSM-5 classification. 'Legal problems' and 'desire to cut down' showed poor discrimination between classes. The weighted prevalence of OUD using DSM-5 was 20.7% higher than with DSM-IV.

CONCLUSIONS:

 RESULTS support the grouping based on severity of symptoms, combining abuse and dependence into a single diagnosis, omitting legal problems, and addition of craving as a new criterion.

  http://www.ncbi.nlm.nih.gov/pubmed/25676055

 


 

Prescription drugs, alcohol, and illicit substance use and their correlations among medical sciences students in iran.

 Abbasi-Ghahramanloo A1, Fotouhi A1, Zeraati H1, Rahimi-Movaghar A2.

Author information

 Abstract

BACKGROUND:

 Substance use among young people is a major public health problem in Iran.

OBJECTIVES:

 The aims of the present study were to determine the prevalence of substance misuse and its determinants in medical sciences students in Tehran, Iran.

PATIENTS AND METHODS:

 A cross-sectional study was performed on a randomly selected sample of 1992 medical sciences students during 2012-2013. Anonymous, structured questionnaires were distributed among the students in each selected class. Substance misuse was defined according to cultural and epidemiological features. Data analysis was performed using chi-squared test, Fisher's exact test, and binary logistic regression.

RESULTS:

 The prevalence of prescription drug misuse, last year alcohol use, and ever illicit substance use was 4.9%, 6.9%, and 2.9%, respectively. The result of multiple logistic regression model showed that being a male (OR = 4.0), hookah use in the last year (OR = 3.2), prescription drug misuse (OR = 3.2), and alcohol use in the last year (OR = 3.3) were associated with the students' illicit substance use. Last year alcohol use (OR = 5.3), ever illicit substance use (OR = 3.2), and illicit substance use in friends (OR = 2.6) were associated with prescription drug misuse.

CONCLUSIONS:

 Our results suggested that the prevalence of prescription drugs, alcohol and illicit substance use was relatively low, though still significant, among Iranian students, which was strongly associated with family and friends' use. The findings of this research can be used for planning and evaluating interventions by considering the risk factors and protective factors in Universities.

 

 

  Swimming improves the emotional memory deficit by scopolamine via mu opioid receptors

  By: Nasehi, M (Nasehi, Mohammad)[ 1 ] ; Nasehi, M (Nasehi, Maryam)[ 2 ] ; Rahmani-Nia, F (Rahmani-Nia, Farhad)[ 2 ] ; Mirzaei, B (Mirzaei, Bahman)[ 2 ] ; Torabi-Nami, M (Torabi-Nami, Mohammad)[ 5 , 6 ] ; Zarrindast, MR (Zarrindast, Mohammad-Reza)[ 3 , 4 , 7 , 8 ]

  PHYSIOLOGY & BEHAVIOR

  Volume: 128

  Pages: 237-246

  DOI: 10.1016/j.physbeh.2014.02.011

  Published: APR 10 2014

  View Journal Information

  Abstract

  Aims: The aim of the present study was to investigate the effect of swimming exercise on elevated plus-maze (EPM)-associated memory deficit induced by intra-CA1 injection of scopolamine (a muscarinic acetylcholine receptor antagonist used to model Alzheimer's disease in rodents) in male mice. In addition, involvement of the mu opioid receptors in this phenomenon was investigated.

Main methods: Bilateral guide cannulae were implanted to allow intra-CA1 microinjections.

Key findings: Data showed that mice with 10 and 20 days of swimming, only acquired the emotional memory, while 30 days of swimming exercise improved it. On the other hand, pretest intra-CA1 injection of scopolamine at the doses of 2 and 3 but not 1 mu g/mouse reduced the emotional memory. Our results demonstrated that 20 days of swimming by itself and without any drug injection restored the emotional memory deficit induced by intra-CA1 injection of scopolamine, only at the dose of 2 but not 3 mu g/mouse. Moreover, once daily injection of the subthreshold doses of morphine (2.5 and 5 mg/kg, i.p.) during the last 7 days of the 20 day-swimming intervention, improved the emotional memory deficit induced by scopolamine (3 mu g/mouse) and this effect could be blocked by the subthreshold doses of naloxone (0.2 and 0.4 mg/kg). It was noted that all previous interventions did not alter the anxiety-like behaviors.

Significance: Swimming improved the emotional memory by itself and restored the emotional memory deficit induced by the intra-CA1 injection of scopolamine. Mu opioid receptor-dependent mechanism(s) is(are) suggested to play a role in this phenomenon. (C) 2014 Elsevier Inc. All rights reserved.

  http://apps.webofknowledge.com/InboundService.do?SID=V12d6CDP%40k5oGe7dii%40&product=WOS&UT=000335106200034&SrcApp=CR&DestFail=http%3A%2F%2Fwww.webofknowledge.com&Init=Yes&action=retrieve&Func=Frame&customersID=ResearchSoft&SrcAuth=ResearchSoft&IsProductCode=Yes&mode=FullRecord

 


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 Int J High Risk Behav Addict. 2015 Mar 20;4(1):e21945. doi: 10.5812/ijhrba.21945. eCollection 2015.

Prescription drugs, alcohol, and illicit substance use and their correlations among medical sciences students in iran.

 Abbasi-Ghahramanloo A1, Fotouhi A1, Zeraati H1, Rahimi-Movaghar A2.

Author information

Abstract

BACKGROUND:

 Substance use among young people is a major public health problem in Iran.

OBJECTIVES:

 The aims of the present study were to determine the prevalence of substance misuse and its determinants in medical sciences students in Tehran, Iran.

PATIENTS AND METHODS:

 A cross-sectional study was performed on a randomly selected sample of 1992 medical sciences students during 2012-2013. Anonymous, structured questionnaires were distributed among the students in each selected class. Substance misuse was defined according to cultural and epidemiological features. Data analysis was performed using chi-squared test, Fisher's exact test, and binary logistic regression.

RESULTS:

 The prevalence of prescription drug misuse, last year alcohol use, and ever illicit substance use was 4.9%, 6.9%, and 2.9%, respectively. The result of multiple logistic regression model showed that being a male (OR = 4.0), hookah use in the last year (OR = 3.2), prescription drug misuse (OR = 3.2), and alcohol use in the last year (OR = 3.3) were associated with the students' illicit substance use. Last year alcohol use (OR = 5.3), ever illicit substance use (OR = 3.2), and illicit substance use in friends (OR = 2.6) were associated with prescription drug misuse.

CONCLUSIONS:

 Our results suggested that the prevalence of prescription drugs, alcohol and illicit substance use was relatively low, though still significant, among Iranian students, which was strongly associated with family and friends' use. The findings of this research can be used for planning and evaluating interventions by considering the risk factors and protective factors in Universities.

 

  http://www.ncbi.nlm.nih.gov/pubmed/25821750


Iranian Journal of Epidemiology

 Volume 10, Issue 4, 2015, Pages 78-88

Scientometrics: Review of concepts, applications, and indicators (Review)

 Yazdani, K.a,

 Nedjat, S.b,

 Rahimi-Movaghar, A.c,

 Ghalichee, L.d,

 Khalili, M.e

  

 a Department Of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
b Department of Epidemiology and Biostatistics, School of Public Health, Knowledge Utilization Research Center, Tehran University Of Medical Sciences, Tehran, Iran
c Iranian National Center for Addiction Studies (INCAS), Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran

 View additional affiliations

 View references (38)

Abstract

 Background and Objectives: In the current age, due to the increasing growth of knowledge and competition therein, evaluation of scientific products by means of scientometric methods has become a very important and necessary subject. Scientometrics, in simple words, is the science of measuring the knowledge. Scientometric indices are divided into three categories: productivity metrics that measure the productivity of the researchers or research groups, impact metrics that assess the quality (or performance) of journals, researchers, or research groups, and hybrid metrics that are used to summarize both productivity and effect metrics in one index. Scientometric studies help policy makers and managers of universities and heads of research centers in allocating budget, creating a balance between the budget and costs, making appointments, and promoting the researchers and institutes, and results in better recognition of weaknesses and strengths of their affiliated groups by evaluation of priorities, perspectives, and capacities. Meanwhile, this new knowledge can help with systematic evaluation and ranking of universities and research centers. This paper provides a review on scientometric concepts and its applications and discussed scientometric indices. © 2015, Iranian Journal of Epidemiology. All right reserved.

  http://www.scopus.com/record/display.url?eid=2-s2.0-84924955071&origin=inward&txGid=C69B8FDECE15A848AD29BBE1E24FA2E4.mw4ft95QGjz1tIFG9A1uw%3a1

 


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 Int J Community Based Nurs Midwifery. 2015 Jan;3(1):39-50.

Vaginal Delivery vs. Cesarean Section: A Focused Ethnographic Study of Women's Perceptions in The North of Iran.

 Zakerihamidi M1, Latifnejad Roudsari R2, Merghati Khoei E3.

Author information

 Abstract

 BACKGROUND:

 Cesarean section (C-section) in the North of Iran accounts for 70% of childbirths, which is higher than the national average of 55%. Understanding women's perceptions towards modes of delivery in different cultures can pave the way for promoting programs and policies in support of vaginal delivery. We aimed to investigate women's perceptions towards modes of delivery in the North of Iran.

METHODS:

 Using a focused ethnographic approach and purposive sampling, 12 pregnant women, 10 women with childbirth experience, nine non-pregnant women, seven midwives, and seven gynecologists were selected from hospitals, healthcare centers, and clinics of Tonekabon and Chaloos, Mazandaran, Iran, during 2012-2014. Data were collected through in-depth interviews and participant observation. Data analysis was performed using thematic analysis using MAXqda software.

RESULTS:

 Two major themes emerged from the data including: "vaginal delivery, a facilitator of women's physical and mental health promotion", and "C-section, a surgical intervention associated with decreased labor pain". Six sub-themes subsumed within these major themes were: vaginal delivery as a safe mode of delivery, fullfilment of maternal instinct, a natural process with a pleasant ending, and C-section as a procedure associated with future complications, a surgical intervention and sometimes a life saving procedure, and a painless mode of delivery.

CONCLUSION:

 In the North of Iran, women's justified cultural beliefs overshadow their micsconceptions, so it is hopped that through implementing appropriate training programs for raising awarness and correcting miscomceptions, vaginal delivery could be promoted even in regions with high rates of cesarean section.

  http://www.ncbi.nlm.nih.gov/pubmed/25553333

 


 

  The Effectiveness of the Life Skills and Problem-Solving Training on Increasing Coping Stress among Addicts under Treatment with Buprenorphine

 

  MARTINIA

  ISSN: 0297-0902

 

  Hossein Gharaati Sotudeh , Hossnieh Goodarzi2, Ameneh Moazedian3, Tahereh Pashaei4*

  

  Abstract

  The purpose of this study, was to investigate the effect of life skills and problem-solving training on increasing coping stress among addicts. The design of the study is semi-experimental with pretest -posttest and control group. The population of the study was all addicts referred voluntarily to Opioids Behzisty’s centers in Tehran. 30 addicts were randomly allocated into experimental group (N=15) and control group (N=15). The life skills and problem-solving training was demonstrated in 8 weekly sessions on the experimental group while the control group received only the Agonist. Coping stress method (CS-R) questionnaire ( ) were completed by both groups before and after intervention. The data was analyzed by covariance analysis method. There was significant difference in coping stress between two groups after intervention. Results demonstrated that the life skills and problem-solving training lead to significant increase in experimental group’s coping stress. Regarding to effectiveness of the life skills and problem-solving on coping stress, it may also be used as a supplement method decreasing stress among addicts.

  http://martinia.com/archive9.html